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KMID : 1123920120260030287
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 3 p.287 ~ p.292
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Apoptotic Effects of Curcumin on the Epstein-Barr Virus-Transformed Human B Lymphoma Cells Activated by PWM
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Ryu Snag-Chae
Lee Jang-Suk
Chong Myong-Soo
Lee Ki-Nam
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Abstract
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The results of this study intended to clarify the apoptotic effects of curcumin on Epstein-Barr virus transformed human B lymphoma (EBV-B) cells are summarized as follows: It was found that curcumin induced endoplasmic reticulum(ER) stress as well as apoptotic cell death in EBV-B cells, although the magnitude of action was insignificant. When EBV-B cells activated by pokeweed mitogen (PWM) were treated with the same concentrations of curcumin, it was found that higher ER stress (GRP78, P-PERK, XBP-1, ATF6, and CHOP expressed) increased unfold protein response (UPR) and thus, apoptosis attributed to ER stress, compared to non-activated EBV-B cells In conclusion, it is expected that curcumin will play an important role for leukemia treatment.
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KEYWORD
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curcumin, epstein-barr virus transformed human B lymphoma, PWM (Pokeweed mitogen), endoplasmic reticulum stress response, apoptotic cell death
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